Author

Jeremy A. Hollis

University of WashingtonORCID 0000-0003-3375-8937Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Evolutionary Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:zebrafish· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Harmit Singh MalikiD· 2 shared Melody G. CampbelliD· 2 shared Alejandro R. BurgaiD· 1 shared Aleq Adrianne R. Andresan· 1 shared Alexander SchleifferiD· 1 shared Andrea PauliiD· 1 shared Andreas BlahaiD· 1 shared Cecilia B. MoensiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersEvolutionary Biology

Harmit Singh MalikORCID

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3 papers

Recent·Most cited

Evolutionary BiologyScience AdvancesPeer-reviewedJul 1, 2026

Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans

Jeremy A. Hollis, Jason A. Stonick, Irini Topalidou…·Harmit Singh Malik

The paper identifies previously unknown Scm3/HJURP orthologs in metazoans using remote homology, structural modeling, and functional genetics, revealing their conserved role in centromere function despite sequence divergence.

DOI 10.1126/sciadv.aeg5356

zebrafishC. elegans

𝕏 PostBluesky

Developmental BiologybioRxivPreprintMay 15, 2026

The SPARK complex forms the molecular basis of vertebrate fertilization

Victoria E. Deneke, Johannes P Suwita, Haoting Wang…·Andrea Pauli

This study identifies SPARK as a conserved multi-protein complex essential for vertebrate fertilization, linking gamete recognition to membrane fusion.

DOI 10.64898/2026.05.13.724128

zebrafishmouse

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Molecular BiologyScience AdvancesPeer-reviewedSep 10, 2025

Evolutionary origin and structural ligand mimicry by the inserted domain of alpha-integrin proteins

Jeremy A. Hollis, Matthew C. Chan, Harmit Singh Malik, Melody G. Campbell

The paper investigates the evolutionary origin and structural role of the I domain in integrin proteins, showing it mimics ligands to enable activation and expand cellular communication.

4 citations

protein structureexperimental assay

𝕏 PostBluesky