Cell BiologybioRxivPreprint
Clonal hematopoiesis-associated DNMT3A mutations derepress bivalent Polycomb target genes and enhance macrophage migration
DOI 10.64898/2026.09.24.754138
Author
Ivan Marazzi
University of California, IrvineORCID 0000-0003-3376-0922Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 28 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- Molecular BiologyGenes & DevelopmentPeer-reviewed
The competition between splicing and 3' processing shapes the human transcriptome
Lindsey V. Soles, Shuangyu Li, Liang Liu…·Yongsheng Shi
The paper shows that splicing and 3' processing compete to shape the human transcriptome, with splicing inhibition activating 3' processing and vice versa.
4 citations - Systems BiologybioRxivPreprint
Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferon
Anthony T. Bejjani, Alec P. Pankow, Ava R. Lamberty…·Emily R. Miraldi
The paper characterizes gene regulatory networks in human airway epithelial cells and identifies cell type-specific responses to type I interferon.
- GenomicsEpigenetics & ChromatinPeer-reviewed
Convergent DNA Methylation Abnormalities at Bivalent Chromatin in Human Growth Disorders
Marie E. S. Wheeler, Yoshiko Takahashi, Jihye Lee…·Minji Byun
This study identifies locus-specific DNA methylation defects at bivalent chromatin as a common feature in growth disorders caused by DNMT3A or NSD1 mutations.
DOI 10.1186/s13072-025-00650-1 - Molecular BiologyNature Structural & Molecular BiologyPeer-reviewed
The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3' processing machinery
Liang Liu, Angela M Yu, Xiuye Wang…·Yongsheng Shi
The paper identifies sequence-specific sensitivity to JTE-607 in mRNA 3' processing by analyzing over 260,000 sequence variants and developing a predictive model.
- GenomicseLifePeer-reviewed
HNRNPM controls circRNA biogenesis and splicing fidelity to sustain prostate cancer cell fitness
Jessica Ho, Federico Di Tullio, Megan Catherine Schwarz…·Ernesto Guccione
This study identifies HNRNPM as a splicing factor critical for prostate cancer cell growth by regulating splicing fidelity and circRNA biogenesis, suggesting it as a therapeutic target.
57 citationstop 5% - MicrobiologybioRxivPreprint
Discovery Of UFO Proteins: Human-Virus Chimeric Proteins Generated During Influenza Virus Infection
Yixuan Ma, Matthew Angel, Guojun Wang…·Ivan Marazzi
The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.