Ernesto Guccione

The paper shows RAF/MEK glues enable full-dose combination with pan-RAF inhibitors, enhancing tumor-selective MAPK inhibition and tumor regression in RAS-mutant models.

This paper develops MINDS, a multispecific nanobody-Fc platform that co-depletes membrane receptors and delivers diverse payloads, showing improved antitumor activity in cancer models.

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

This study identifies PRDM9 as a factor promoting survival of drug-tolerant persister cells in glioblastoma through metabolic rewiring and cholesterol biosynthesis.

This study shows that CDK2L and CDK2S isoforms are functionally redundant in supporting both mitotic and meiotic divisions in mice.

This study identifies an oncofetal cell state that contributes to resistance in colorectal cancer and shows that targeting both this state and LGR5+ CSCs is needed for effective treatment.

The paper identifies anti-correlated gene selection as a method to prevent false discovery of subpopulations in scRNA-seq by reducing erroneous subdivisions in clustering.

This paper benchmarks scRNAseq clustering pipelines using a self-supervised approach, identifying a novel metabolic gene signature linked to hepatocellular carcinoma survival.

This paper shows that common scRNA-seq batch correction methods erase biological variation, and proposes new measures to assess batch effects and their impact on cluster composition and topologies.

This study identifies HNRNPM as a splicing factor critical for prostate cancer cell growth by regulating splicing fidelity and circRNA biogenesis, suggesting it as a therapeutic target.

This study identifies Npac as a co-factor of H3K36me3 that regulates transcriptional elongation in mouse ESCs by interacting with p-TEFb and RNA Pol II.

This study shows that G9a inhibition reduces DKK1 expression and enhances Wnt signaling, promoting myogenic differentiation in ERMS cells.