Qun Lu

This study identifies a small molecule, SCC944, that targets ARF1-CSW interactions and reduces GTP-bound ARF1, showing potential as a therapeutic for ALS/FTD.

The paper shows that KHSRP-mediated decay of axonal Prenyl-Cdc42 mRNA slows nerve regeneration by regulating mRNA stability and transport in response to growth signals.

The paper constructs a spatial transcriptomic atlas of capillary malformations, identifies EndMT and AJ disruption, and shows NR2F2 drives SMC phenotype acquisition in vascular lesions.

This study systematically identifies and classifies Cdc42 homeostatic modulators using a combination of experimental profiling and computer-aided drug discovery, revealing five functionally distinct classes with potential therapeutic applications.

The paper shows that prenyl-Cdc42 mRNA localizes to PNS axons and promotes axon growth through localized translation and prenylation.