John Blenis

This study shows that mineralocorticoid receptor (MR) and phosphorylated glucocorticoid receptor (p-GR) interaction promotes triple-negative breast cancer (TNBC) metastasis through migratory, stemness, and fibrotic mechanisms.

This study shows that propionate metabolism dysregulation, through MMA accumulation and EMT activation, promotes drug-tolerant persister cell survival in NSCLC.

This study shows that invasive cancer cells use lysosome-mediated nutrient scavenging during EMT, bypassing plasma membrane transport, and that this process is regulated by c-MYC downregulation.

This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.

This study identifies LKB1's role in suppressing growth by activating PIKFYVE to promote EGFR internalization in LUAD.

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.