Cell BiologyAmerican Journal of Physiology-Lung Cellular and Molecular PhysiologyPeer-reviewed
PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hy-pertension
Tatiana V. Kudryashova, Sergei V Zaitsev, Lifeng Jiang…·Victoria V. Stepanova
This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.