Author

Chamika De Silva

University of Massachusetts Chan Medical SchoolORCID 0000-0003-3846-4313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Dannel McCollumiD· 2 shared Brian A. KelchiD· 1 shared Ishani DasguptaiD· 1 shared Natasha Cruz‐Calderon· 1 shared Samriddha Ray· 1 shared Sebastian Mana‐Capelli· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

Dannel McCollumORCID

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2 papers

Recent·Most cited

Cell BiologyPLoS ONEPeer-reviewedFeb 2, 2026

Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions.

Chamika De Silva, Brian A. Kelch, Dannel McCollum

This study identifies the molecular mechanism by which LIMD1 recruits LATS1/2 to adherens junctions through LIM domains and an N-terminal IDR, mediated by a conserved LATS-LATCH motif.

2 citations

experimental assaycell signaling & trafficking

𝕏 PostBluesky

Cell BiologyCytoskeletonPeer-reviewedMar 1, 2024

The ability of the LIMD1 and TRIP6 LIM domains to bind to f-actin under strain is critical for their tension dependent localization to adherens junctions and association with the Hippo pathway kinase LATS1.

Samriddha Ray, Chamika De Silva, Ishani Dasgupta…·Dannel McCollum

This study shows that TRIP6 and LIMD1 bind to strained actin, enabling their localization to adherens junctions and interaction with LATS1, a key Hippo pathway kinase.

5 citations

experimental assaycell signaling & trafficking

𝕏 PostBluesky