Dannel McCollum

This study identifies the molecular mechanism by which LIMD1 recruits LATS1/2 to adherens junctions through LIM domains and an N-terminal IDR, mediated by a conserved LATS-LATCH motif.

The paper identifies a regulatory mechanism involving Sty1 and Orb6 kinases that controls Cdc42 dynamics during stress, leading to changes in cell morphology and lifespan.

This study shows that TRIP6 and LIMD1 bind to strained actin, enabling their localization to adherens junctions and interaction with LATS1, a key Hippo pathway kinase.