Author

Junhui Li

University of Massachusetts Chan Medical SchoolORCID 0000-0003-3973-1700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Lihua Julie ZhuiD· 3 shared Jason Robert PitarresiiD· 2 shared Jessica PeuraiD· 2 shared Katherine C. MurphyiD· 2 shared Kelly D. DeMarcoiD· 2 shared Marcus A. RuscettiiD· 2 shared Arthur M. MercurioiD· 1 shared Boyang MaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCancer Biology

Lihua Julie ZhuORCID

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3 papers

Recent·Most cited

Cancer BiologyJournal of Biological ChemistryPeer-reviewedAug 10, 2026

Insulin receptor substrate 2 (IRS2) confers resistance to PI3K pathway inhibition in PIK3CA mutant breast cancer

Michael W. Lero, Jennifer S. Morgan, Michael-Anthony Card…·Leslie M. J. Shaw

This study identifies IRS2 as a mediator of resistance to PI3K pathway inhibitors in PIK3CA mutant breast cancer by sustaining PI3K signaling through FOXO3-mediated regulation.

DOI 10.1016/j.jbc.2026.113426

humanbulk RNA-seq

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Cancer BiologyCancer ResearchPeer-reviewedSep 3, 2025

MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

Katherine C. Murphy, Kelly D. DeMarco, Lin Zhou…·Marcus A. Ruscetti

This study shows that MYC and p53 alterations in prostate cancer cooperate via VEGF signaling to suppress T cell activity and immunotherapy responses, and that targeting VEGFR2 can enhance immunotherapy efficacy.

10 citationstop 5%

mousehuman

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Cancer BiologyScience Translational MedicinePeer-reviewedAug 28, 2024

Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer

Loretah Chibaya, Kelly D. DeMarco, Christina F. Lusi…·Marcus A. Ruscetti

This paper combines nanoparticle-delivered immune agonists with senescence-inducing agents to enhance T cell responses and control pancreatic cancer in preclinical models.

76 citationstop 1%

mousehuman

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