Jessica Peura

This study shows that MYC and p53 alterations in prostate cancer cooperate via VEGF signaling to suppress T cell activity and immunotherapy responses, and that targeting VEGFR2 can enhance immunotherapy efficacy.

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.

This study shows that mitochondrial Ca2+ uptake via MCU promotes pancreatic cancer growth and metastasis by enhancing epithelial plasticity through EMT.

This paper combines nanoparticle-delivered immune agonists with senescence-inducing agents to enhance T cell responses and control pancreatic cancer in preclinical models.