Ville Hoikkala

This study examines a chromosomal inversion in Drosophila montana, finding it enriched with adaptive and barrier loci, suggesting inversions help maintain adaptive allelic combinations and reduce gene flow.

This study describes the structure and mechanism of Crn4, a ring nuclease that degrades cyclic oligoadenylates and modulates type III CRISPR immunity.

The paper shows that a viral SAVED domain, AcrIII-2, degrades the CRISPR second messenger cA4, inhibiting its effectors.

The paper analyzes type III CRISPR-Cas loci across 38,742 prokaryotic genomes to identify and characterize ring nucleases that regulate cyclic oligoadenylate levels.

This study identifies SAM-AMP as a novel second messenger in type III-B CRISPR systems, used for antiviral signaling by conjugating ATP to S-adenosyl methionine.