Author
University of St AndrewsORCID 0000-0003-4273-8364Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Yu Sun, Stephen A. McMahon, Silvia Snyowsky, Malcolm F. White
The paper describes a dimeric TIR effector, TSR1, that binds cA3 and degrades it to auto-limit its activity in type III CRISPR-mediated antiviral immunity.
Haotian Chi, Stephen A. McMahon, Shirley Graham, Malcolm F. White
This study investigates the structural and biochemical properties of Csx15, a ring nuclease that binds cyclic nucleotides and regulates antiviral defense by modulating cOA levels.
Haotian Chi, Ville Hoikkala, Stephen A. McMahon…·Malcolm F. White
This study describes the structure and mechanism of Crn4, a ring nuclease that degrades cyclic oligoadenylates and modulates type III CRISPR immunity.
Sabine Grüschow, Stuart McQuarrie, Katrin Ackermann…·Malcolm F. White
This study identifies Csx23 as a CRISPR effector that uses cyclic nucleotide binding to mediate antiphage defence in Vibrio cholerae.