Simon H. J. Brown

This study determines cryo-EM structures of bacterial DNA polymerase III complexes to elucidate the mechanism of nucleotide incorporation and proofreading.

This paper investigates the role of the lower γ region in F1-ATPase rotation, finding it contributes to unidirectional rotation and torque generation specifically in the latter half of the 0-80° step.

This paper reports the high-resolution structure of a viral:host hetero-amyloid complex between M45 and RIPK3, revealing its mechanism of inhibiting necroptosis.

This study identifies TAM as a bacterial phospholipid transport system, revealing its structure and mechanism for lipid delivery to the outer membrane.

The paper characterizes the functional and structural properties of an ancestral F1-ATPase, revealing it was originally a 6-stepper that diversified into 3-, 6-, and 9-step forms.

This study reports the high-resolution cryo-EM structure of native human nucleosomes from HEK293 cells and provides mass spectrometry analysis of histone modifications.

The paper reports the cryo-EM structure of human DET1 in complex with DDB1-DDA1 and Ube2e2, revealing how DET1 dynamics facilitate COP1 recruitment and ubiquitination.

The paper solves the cryo-EM structure of an axle-less F1-ATPase and shows that the complete γ subunit is important for efficient ATP binding.

This study presents six high-resolution structures of the E. coli clamp loader complex (CLC) during the clamp loading process, revealing the molecular mechanism of clamp opening and DNA binding.

This paper describes a chemical method to modify graphene oxide surfaces with amine-reactive groups for biochemical interactions in aqueous buffer.