Jonathan Hurtado

This study evaluates MoE architectures for antibody language models, finding token-choice routing improves performance by specializing in CDRH3 residues and enabling efficient pre-training.

This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.

This study vaccinates nonhuman primates with SARS-CoV-2 and MERS-CoV spike proteins to elicit cross-reactive antibodies that neutralize both sarbecoviruses and merbecoviruses.

This study profiles B cell development using single-cell RNA sequencing, revealing proliferative bursts after recombination and repertoire changes during lymphopoiesis.

This study derives a scaling law for antibody language models, showing that performance improvements require both large model size and sufficient data.

This study shows that targeting the conserved HIV fusion peptide with modified Env immunogens in rhesus macaques can focus immune responses on neutralizing epitopes.

This paper uses AI to predict and stabilize the conformational states of Lassa virus GPC, identifying vaccine candidates with improved expression and antigenicity.

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.