Dennis R. Burton

This study shows that mRNA vaccines can prime and mature ultrarare HIV bnAb precursor B cells in NHPs, with improved affinity using a modified immunogen.

The paper shows that early clonal dominance in B-cell precursors after vaccination predicts the breadth of HIV-neutralizing antibodies in rhesus macaques.

This study tracks germinal center responses in rhesus macaques over a year, showing prolonged GCs with declining SHM and ongoing plasma cell production.

Epitope-focused S2 stem-helix nanoparticle immunogens elicit protective broadly neutralizing antibodies against diverse betacoronaviruses in non-human primates, establishing a framework for pan-betacoronavirus vaccines.

This paper describes the directed evolution of an antibody to enhance its binding affinity for MERS-CoV, resulting in cross-neutralization against multiple betacoronaviruses.

The paper analyzes changes in the human antibody repertoire over four years using high-throughput sequencing, finding conservation of broad features but changes in fine details.

This study characterizes the structure and function of antibodies targeting the conserved β-epitope region of PfCSP, showing how they achieve strain-transcending recognition and enhance Fc-mediated immune responses.

This study uses deep learning to design multi-epitope scaffolds mimicking CSP's spatial structure, showing accurate positioning of two epitopes and partial success with the third.

This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.

This study vaccinates nonhuman primates with SARS-CoV-2 and MERS-CoV spike proteins to elicit cross-reactive antibodies that neutralize both sarbecoviruses and merbecoviruses.

The paper designs native-like HIV Env single-chain trimers (SCTs) that are stable, immunogenic, and compatible with vaccine delivery methods.

This study improves HIV broadly neutralizing antibodies through multistate engineering, resulting in enhanced breadth and potency against diverse Env variants.

This study shows that a single immunization with a germline-targeting trimer can induce broad HIV-1 neutralizing antibodies in a rhesus macaque bnAb mouse model.

This study shows combining a RhCMV/SIV vaccine with neutralizing antibodies enhances protection against SIV challenge in rhesus macaques.

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

This study evaluates the dose-dependent effects of the SMNP adjuvant on HIV Env-specific immune responses in non-human primates, showing increased memory T and B cell responses and neutralizing antibodies at higher doses.

This study shows that the S2-targeting antibody CC40.8 reduces SARS-CoV-2 viral loads and lower airway inflammation in rhesus macaques, supporting its potential as a broad coronavirus vaccine strategy.

This study compares the immune response in non-human primates between alum and SMNP adjuvants, finding SMNP induces stronger humoral responses and enhanced lymph node activation.

This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.

This study investigates whether engineering HIV Env trimers or using gp120 can induce broadly neutralizing antibodies in cows, finding that trimers are more effective than monomeric gp120.

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

This study identifies three non-overlapping B-cell epitope regions in the N-terminus of Plasmodium falciparum CSP using monoclonal antibodies from immunized mice.

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

The paper identifies a conserved 166-gene host immune signature across viral pandemics, with a 20-gene subset predicting disease severity and guiding therapeutic strategies.

The paper develops ab[x], a scalable software toolkit for genetic analysis of antibody repertoire data, including cloud deployment, preprocessing, and downstream analysis tools.

This paper describes a method to sequence Zika and other virus genomes directly from clinical samples using multiplex PCR and portable sequencing technologies, achieving complete genomes in 1-2 days.

The paper develops a single-cell barcoding method to capture immune receptor sequences from tumor-infiltrating lymphocytes without sorting or culturing, demonstrating its application on ovarian cancer samples.