Lei Zheng

This study identifies SEMA3D as a dual driver of pancreatic ductal adenocarcinoma progression and metastasis through tumor- and nerve-derived mechanisms involving macrophage reprogramming.

This study uses spatial multi-omics to identify TLS-associated immune niches in PDAC that correlate with improved survival in immunotherapy responders.

This study compares scRNA-seq of unenriched and CAF-enriched samples from PDAC tumors, finding that CAF enrichment better captures heterogeneity but loses other TME cells.