Zhaoyong Hu

The paper shows that intermittent AP-1 activation in muscles mimics exercise benefits, improving mitochondrial function and glucose tolerance.

This study identifies ROCK1 activation as a driver of mitochondrial fission and oxidative stress in CKD-induced muscle wasting, showing pharmacological inhibition of ROCK1 can alleviate these effects.

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

This study uses snRNA-seq to analyze denervated muscle, identifying transcriptional changes in specific myonuclei subtypes and revealing gene regulatory networks and metabolic shifts associated with muscle atrophy.