Jon E. Levine

The paper identifies genes and regulatory networks driving electrophysiological maturation of neurons in primate prefrontal cortex, with implications for autism.

The paper shows that genome editing in the striatum leads to fluorescent reporter expression in the substantia nigra pars reticulata via anterograde axonal transport.

This study develops non-viral nanocapsules for in vivo CRISPR-Cas9 delivery to edit neuronal DNA in mice, achieving efficient and safe genome editing in specific neuron types.