Shaoqin Gong

The paper uses CRISPR screening to identify genes that enhance nonviral genome editing efficiency in human cells, finding six genes that increase editing efficiency by up to five-fold.

This study demonstrates that targeted NAD+ delivery via nanocarriers reduces intimal hyperplasia and promotes endothelial regeneration in a rat model of restenosis.

This study develops non-viral nanocapsules for in vivo CRISPR-Cas9 delivery to edit neuronal DNA in mice, achieving efficient and safe genome editing in specific neuron types.

This study develops GSH-responsive silica nanocapsules for systemic delivery of CRISPR components across the blood-brain barrier, achieving gene editing in the brain.

This paper demonstrates nonviral base editing of a KCNJ13 mutation in a mouse model of retinal degeneration, preserving vision through functional rescue of Kir7.1 channels.

This study shows that PERK inhibition reduces restenosis and thrombosis in animal models, suggesting it as a potential therapeutic strategy for drug-eluting stents.