Christine Y. Yeh

This study shows that cancer cell phagocytosis by macrophages induces an anti-inflammatory gene regulatory program, promoting immunosuppression and tumor growth.

This paper introduces DR-GEM, a self-supervised meta-algorithm for single-cell data that improves embeddings and annotations by reducing overfitting and noise.

The paper uses spatial imaging and computational analysis to identify features in metastatic tumors that predict response to immune checkpoint inhibition in TNBC patients.

This study identifies molecular signatures of brain mimicry and adaptation in breast cancer brain metastases using spatial transcriptomic profiling and a new algorithm called Equivalent Expression Index.

This study maps ovarian cancer spatial organization and identifies immune evasion drivers through single-cell spatial transcriptomics and CRISPR screens.

This study uses single-cell transcriptomics to identify gene regulatory networks and lineage trajectories in human fetal thymic epithelial cells, revealing interferon response pathways that distinguish thymic epithelium from other anterior foregut-derived organs.

The paper introduces REMI, a graph-based method to reconstruct cell-cell interactions in lung adenocarcinoma by accounting for ligand-receptor dependencies, and validates its findings experimentally.