Obinna Chijioke

The paper identifies MTAP deficiency as a biomarker in lung neuroendocrine neoplasms, distinguishing carcinoids from SCLC and LCNEC, and shows it is not caused by 9p21 deletion or promoter hypermethylation.

This study performs a single-cell transcriptomic analysis of EBV-responsive lymphocytes in healthy and immunodeficient individuals, identifying key immune mechanisms and potential therapeutic targets.

This study develops bispecific antibodies targeting IGLV3-21R110 to selectively kill high-risk CLL cells while sparing healthy B cells and stem cells.

This study shows EBV infection induces tissue-resident memory T cells in mucosal lymphoid tissues in mice with humanized immune systems, but these TRMs fail to control viral loads compared to systemic effector memory T cells.

This study establishes an immunocompetent humanized tumor model and identifies exhausted-like CD8+ T cells with antitumor activity in vivo.

This study develops CAR T cells targeting a specific mutation in CLL to selectively kill cancer cells while sparing healthy B cells.