Philip Tinnefeld

This paper introduces MARs, magnetic molecular nanorulers that measure molecular distances and enable combinatorial biosensing with high accuracy and resolution.

This paper introduces an AI-based framework for designing responsive protein oligomers that assemble in response to chemical or phosphorylation triggers, validated through experimental testing.

This study observes sub-microsecond dynamics of single DNA molecules using graphene-based fluorescence measurements and links findings to structural and environmental factors.

This paper introduces reconfigurable DNA origami arrays as a network of two-state systems to enable multi-stimuli, multi-output nanorobots with controlled logic and timing.

This paper introduces Brownian DNA computing, a molecular computing framework that uses DNA origami scaffolds to implement logic gates and circuits through thermal fluctuations, enabling energy-efficient and reversible computation.

This study localizes Myosin A in Toxoplasma gondii with 1-4 nm axial precision using graphene energy transfer, supporting the linear migration motor model.

This paper introduces a sensitive, non-amplified nucleic acid detection method using DNA origami nanoantennas, achieving attomolar detection without requiring molecular amplification.

The paper introduces a molecular fluorescence lifetime sensor to non-invasively monitor DNA origami coating with cationic polymers or silica in real-time at the single nanostructure level.

This paper infers binding and unbinding rates from fluorescence time series while accounting for photobleaching using a two-stage Bayesian approach.

This paper develops a fluorescent probe to detect malaria-infected red blood cells and demonstrates its use with a smartphone microscope for diagnostic applications.

This paper develops a DNA-mediated photostabilization method for single-molecule and super-resolution imaging, showing improved performance at lower additive concentrations and enabling continuous replenishment of photostabilizers.

This study develops a method to study DNA and DNA-protein interactions with high spatial and temporal resolution using graphene and energy transfer.

This paper introduces modular and tunable single-molecule sensors using DNA origami scaffolds to detect biomolecules with adjustable response windows and specificity.

The paper describes a DNA origami-based biosensor that detects lipid vesicles through smFRET and enables targeted cargo transfer to vesicles.

This paper demonstrates a method using DNA nanoantennas to increase photon count rates in smFRET, enabling observation of fast biomolecular dynamics with improved temporal resolution.

The paper demonstrates how modifying anchor geometry can generate catch bonding behavior in the DocG:CohE adhesion complex, showing mechanical anisotropy enables engineered catch bonds.

The paper introduces a method to create light-activatable DNA processing enzymes and demonstrates their performance in molecular biology assays.