Paul Klenerman

This study shows that CXCR3 on transferred T cells enhances the effectiveness of combining adoptive T-cell therapy with viral-vector vaccines in solid tumors.

The paper shows that gut archaea produce 5-OP-RU, which activates MAIT cells, linking archaea to human immunity.

This paper demonstrates that targeting CD160+ cells with a monoclonal antibody prevents autoimmune-induced myocarditis by depleting NK cells and other cytotoxic T cells, inhibiting multiple inflammatory pathways.

This study identifies genetic risk factors and host-viral interactions for cirrhosis progression in hepatitis C virus-infected patients but finds no genome-wide significant associations for hepatocellular carcinoma.

This study uses human tonsil organoids to investigate innate pathways regulating humoral and cellular responses to ChAdOx1, identifying key roles for IFN- and IL-6.

This study uses scRNA-seq to analyze CSF and blood from TBM patients, identifying inflammatory cell subtypes and altered metabolic pathways in CSF.

The paper identifies early T and NK-cell dysfunction in dengue patients that predicts severe disease, with obesity exacerbating these signatures.

This study analyzes HCV within-host dynamics post-DAA treatment failure, finding persistent viral subpopulations and lineage-specific evolutionary rates.

This study identifies MAIT cells as protective against sterile lung injury by promoting anti-fibrotic pathways through cDC1 accumulation.

This study detects neurodegenerative biomarkers in human cervical lymph nodes, showing higher concentrations than plasma and age-related changes in phospho-Tau-181.

The paper integrates single-cell RNA-seq datasets across the GI tract to identify epithelial metaplasia in inflammatory diseases, showing its role in inflammation through immune cell interactions.

This study uses LN FNA combined with single-cell RNA-sequencing and proteomics to characterize immune cell populations and soluble interactors in human lymph nodes.

The paper identifies mutations in SARS-CoV-2 variants that confer resistance to monoclonal antibodies by analyzing genomic data and validating their impact on antibody neutralization.

The paper defines the transcriptome of activated MAIT cells in mice and humans and shows how it changes during infection phases, revealing a tissue repair phenotype.

The paper examines the impact of IFN-lambda4 on HCV diversity using host and viral genetic data from 485 patients, finding that IFN-lambda4 variants influence viral amino acid diversity and load.