Amy J. Wagers

This study demonstrates CRISPR-HDR efficiency in postnatal cardiac, skeletal muscle, and muscle stem cells, showing developmental stage-dependent HDR rates and successful correction of a Dmd mutation in mdx mice.

This study demonstrates that single-vector adenine base editing via MyoAAV can recode a DMD-causing mutation in mice, with optimal therapeutic outcomes achieved in juvenile animals.

The paper creates a mouse model of premalignant oral squamous cell carcinoma and identifies transcriptomic signatures of premalignancy, including immune response enhancement and stem cell dysregulation.

This study identifies TRIM28's role in satellite cell-mediated myogenesis by regulating myomixer expression and fusion pore formation, independent of phosphorylation or proliferation/differentiation.

This study identifies SRSF1 as a rejuvenation factor through transcriptomic reprogramming, showing it improves cellular function and is linked to longevity.

The paper introduces PRINT, a deep learning method to correct chromatin accessibility data and analyze DNA-protein interactions, revealing structural and functional changes in cis-regulatory elements during hematopoiesis and aging.

The paper shows that Cre recombinase can be transported from somatic tissues to the male reproductive tract in mice, suggesting inter-tissue RNA or protein trafficking.

This study uses single-cell transcriptomics to show that heterochronic parabiosis alters aging signatures in multiple brain cell types, with endothelial cells showing significant transcriptional changes.

The paper investigates the functional differences between GDF11 and GDF8 by substituting amino acids and identifies distinct effects on skeletal development and muscle.

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.