Kazutoyo Miura

This paper improves an anti-malaria antibody to broaden its recognition of malaria parasite proteins and enhances its protective effectiveness against diverse strains.

This study shows that nanoparticle vaccines with oligomannose glycans boost B cell responses and protection against malaria sporozoites compared to other glycan types.

This paper evaluates the cross-reactivity of a recombinant Plasmodium vivax protein with sera from Plasmodium falciparum-exposed individuals and demonstrates its transmission-blocking activity against P. falciparum.

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

This study evaluates the precision of the Plasmodium knowlesi growth inhibition assay for Plasmodium vivax Duffy-binding protein-based malaria vaccine development, finding significant assay-to-assay variation in %GIA and GIA50.