Shristi Shrestha

The paper integrates multiple scRNA-seq datasets to create a comprehensive atlas of human pancreatic islets, identifying 13 cell populations and providing a resource for diabetes research.

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

The paper identifies immune cell dysfunction in adipose tissue of individuals with obesity-associated asthma using single-cell RNA sequencing.

This study shows sustained Yap/Taz activation in alveolar epithelial cells leads to fibrotic remodeling and impaired repair, with potential therapeutic implications.

This study characterizes the vascular structure and function of the choroid plexus using multimodal techniques, revealing developmentally distinct endothelial subtypes and mechanosensitive properties.

This study shows that warmer temperatures accelerate senescence in mosquitoes by altering transcriptome changes related to immunity, metabolism, and DNA repair.

CelLink integrates single-cell multi-omics data by addressing weak feature linkage and imbalanced cell populations, outperforming existing methods in imputation accuracy and cell subtype annotation.

The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.

This study shows caloric restriction enhances beta cell identity and homeostasis, delays aging and senescence, and improves mitochondrial function in pancreatic beta cells.

The paper identifies combinatorial transcription factor expression in human islet cells and shows it correlates with functional maturity and electrophysiological activity.

The paper analyzes single-cell sperm RNA-seq data from fathers of autistic and healthy children to identify mutation clusters and expression differences associated with ASD risk.