Matthew C. Wolfgang

This study shows that loss of flagellar motility in Pseudomonas aeruginosa increases aggregation and antibiotic tolerance in the mucus environment of chronic lung infections.

This study uses thermodynamic modeling to predict RsmA-mRNA binding interactions in Pseudomonas aeruginosa, identifying 1043 interactions including 457 novel targets, validated through experimental assays.

This study shows that increased mucin and eDNA concentrations in mucus enhance Pseudomonas aeruginosa antibiotic tolerance, and establishes an in vitro model to replicate this tolerance observed in sputum.

The paper identifies miR-2392 as a miRNA involved in SARS-CoV-2 infection, showing its role in inflammation, glycolysis, and hypoxia, and develops a miRNA-based therapeutic targeting it.