Lucas M. Plott

This study investigates how C. difficile uses host-derived mucus for growth, metabolism, and biofilm formation, revealing metabolic shifts and potential pathogenic mechanisms.

This study shows that increased mucin and eDNA concentrations in mucus enhance Pseudomonas aeruginosa antibiotic tolerance, and establishes an in vitro model to replicate this tolerance observed in sputum.

This paper tests combination treatments to disrupt Pseudomonas aeruginosa biofilms in mucus, finding that NP40, hyaluronic acid, and tobramycin most effectively increase mucociliary transport and reduce bacterial viability.