Paula V. Schiapparelli

This study identifies cholesterol dependency as a therapeutic target in glioblastoma, showing that combined treatment with clemastine and bexarotene induces metabolic collapse and enhances antitumor immunity.

This study shows that YAP inhibition with verteporfin increases radiosensitivity in chordoma by blocking DNA repair and causing G2M arrest.

This study uses cell-specific proteomics to show that CTSB signaling from glioblastoma cells promotes malignancy by disrupting neurogenesis and inducing senescence in neural progenitor cells near the subventricular zone.

The paper characterizes GSC-derived GBM organoids, revealing an immune-like molecular program and identifying SATB2+ and HOPX+ progenitor populations that contribute to GBM progression.