Jonathan Stuart Serody

This study compares tumor-immune-stromal communication in plasmacytoid urothelial carcinoma (PUC) and conventional urothelial carcinoma (CUC) using single nucleus RNA sequencing and spatial transcriptomics, identifying distinct signaling patterns and potential therapeutic targets.

This paper shows that combining MERTK inhibition with cyclophosphamide enhances anti-tumor immunity in basal-like TNBC by reprogramming macrophages and promoting CD4 T cell responses.

This study shows that combining nanoformulated TLR7/8 agonist and PI3K delta inhibitor with radiotherapy improves anti-tumor activity in TNBC by modulating the tumor microenvironment.

This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.