William Durso

This study shows YIPF5 regulates ER export of specific proteins, and its disruption causes neuronal migration defects and microcephaly.

The paper creates a cell-type-specific lysosome protein atlas in the brain, identifies SLC45A1 as a neuron-specific lysosomal protein, and shows its role in lysosomal function and neurodegeneration.

NanTex enables multiplexing and phenotyping of organelles using nanotexture descriptors from single-channel super-resolution microscopy data across multiple modalities.

This study investigates changes in the synaptic proteome and transcriptome during aging, revealing decoupling between transcripts and proteins and altered ribosomal gene distribution.

The paper identifies YIPF5 and GOT1A/B as components of ER export and shows ATF6 has a transcription-independent role in ER export inhibition by FLI-06.