Ian D. McGilvray

The paper uses whole-genome and transcriptome sequencing to identify two consensus cancer subtypes in biliary tract cancer, revealing divergent molecular landscapes that better explain tumor heterogeneity than anatomical classification.

This paper uses Visium HD spatial transcriptomics to create a high-resolution map of human liver cell types and spatial gene expression in adult and pediatric samples.

The paper maps the multiscale structure of human liver tissue using electron microscopy and deep learning, revealing vascular, cellular, and organelle organization and dynamics.

The paper constructs a single-cell RNA-seq atlas of the human pediatric liver and identifies age-related gene signatures that differ from adult livers and are relevant to pediatric liver diseases.

This study develops a method to generate functional hepatocytes from human pluripotent stem cells through controlled differentiation and tissue engineering.

This paper creates a single-cell atlas of the woodchuck liver to identify cellular programs in health and disease, showing similarities with human HBV infection.

This paper uses single-cell and spatial transcriptomics to map the immune landscape of PSC livers, revealing myeloid dysfunction and cytokine-driven inflammation.

The paper uses single-cell transcriptomics to compare strain-specific differences in myeloid inflammatory potential in healthy rat livers, revealing strain-specific variations in inflammatory signaling pathways.

This study creates a single-cell atlas of human liver development, identifying pathways and factors that guide hepatic cell fates and improving hepatocyte-like cell functionality.