Matthieu Thumerel

The paper develops a tunable 3D-alveolosphere model from human primary AEC2 cells to study emphysema, showing key native alveolar features and pathophysiological responses to cigarette smoke extract.

The paper introduces a bronchioid model using human bronchial stem cells in an alginate scaffold to mimic distal airway structure and function, showing ciliary activity and pathophysiological features.

This study quantifies fibrocyte density in bronchial tissue of COPD patients and controls, finding increased fibrocytes associated with reduced lung function and increased bronchial wall thickness.