Chengshui Chen

This study evaluates the antifibrotic effects of OTR4120 in lung fibrosis models, showing reduced collagen deposition and fibroblast activation.

This study traces Acta2+ cells in aged mice during lung fibrosis to show lipofibroblasts can reversibly switch to myofibroblasts, with similar patterns observed in humans.

This study uses WI-38 cells to investigate the reversible switch between myofibroblast and lipofibroblast phenotypes in lung fibrosis, showing similar transcriptomic responses to treatments and supporting the LIF-MYF switch.

The paper describes the development and validation of a new Fgf10CreERT2 mouse line (Fgf10Ki-v2) that effectively targets Fgf10-positive cells in adult lungs, overcoming limitations of an earlier version.

This study identifies rMC-Sca1PosFgf10Pos cells as a functional population critical for maintaining AT2 stem cell self-renewal and differentiation in mice, with implications for fibrosis and COVID-19 pathogenesis.

This study identifies miR-142's role in regulating alveolar epithelial cell lineage formation through interactions with the glucocorticoid and p300 signaling pathways.

This study identifies a repair-supportive mesenchymal cell population critical for lung epithelial regeneration through single-cell RNA sequencing and lineage tracing.