Savério Bellusci

The paper identifies gene-expression gradients along the lung airway axis and shows FGFR-signaling establishes these gradients postnatally.

This study evaluates the antifibrotic effects of OTR4120 in lung fibrosis models, showing reduced collagen deposition and fibroblast activation.

This study traces Acta2+ cells in aged mice during lung fibrosis to show lipofibroblasts can reversibly switch to myofibroblasts, with similar patterns observed in humans.

This study uses WI-38 cells to investigate the reversible switch between myofibroblast and lipofibroblast phenotypes in lung fibrosis, showing similar transcriptomic responses to treatments and supporting the LIF-MYF switch.

This study shows Fgfr2b signaling is essential for maintaining AT2 cells in adult mouse lungs, with IAAPs acting as potential progenitors.

This study investigates Fgfr2b signaling's role in alveolar epithelial lineage commitment during mouse lung development and injury repair, identifying key regulatory genes and lineage contributions.

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.

The paper describes the development and validation of a new Fgf10CreERT2 mouse line (Fgf10Ki-v2) that effectively targets Fgf10-positive cells in adult lungs, overcoming limitations of an earlier version.

This study identifies rMC-Sca1PosFgf10Pos cells as a functional population critical for maintaining AT2 stem cell self-renewal and differentiation in mice, with implications for fibrosis and COVID-19 pathogenesis.

This study identifies miR-142's role in regulating alveolar epithelial cell lineage formation through interactions with the glucocorticoid and p300 signaling pathways.

This study identifies a repair-supportive mesenchymal cell population critical for lung epithelial regeneration through single-cell RNA sequencing and lineage tracing.