Bernard P. Mari

The paper introduces iSiT, an imaging-based spatial isoform transcriptomics method, and demonstrates its application in the mouse brain to study transcript isoform diversity at cellular and subcellular resolution.

This study identifies AETA peptide as a novel contributor to synaptic dysfunction in Alzheimer's disease, particularly in females, through post-mortem analysis and a mouse model.

The paper uses scRNA-seq to analyze the response of human bronchial epithelial cell types to CdCl2, revealing cell-type-specific transcriptional changes.

This study examines the effects of miR-210 locus deletion on cellular homeostasis in human and mouse cells, revealing deregulation of neighboring genes and unexpected lack of miR-210 target enrichment.

The paper develops a Sparse supervised autoencoder to detect subtle transcriptomic changes from CRISPRi screens of lncRNAs in lung cancer cells under hypoxia.

This study traces Acta2+ cells in aged mice during lung fibrosis to show lipofibroblasts can reversibly switch to myofibroblasts, with similar patterns observed in humans.

This study uses WI-38 cells to investigate the reversible switch between myofibroblast and lipofibroblast phenotypes in lung fibrosis, showing similar transcriptomic responses to treatments and supporting the LIF-MYF switch.

This study identifies miR-142's role in regulating alveolar epithelial cell lineage formation through interactions with the glucocorticoid and p300 signaling pathways.

This study identifies a repair-supportive mesenchymal cell population critical for lung epithelial regeneration through single-cell RNA sequencing and lineage tracing.

This study identifies DNM3OS as a key regulator of fibroblast activation via miRNAs, offering a therapeutic target for fibrotic diseases like IPF.