Sanjid Shahriar

This study shows that SOX7 and ERG reprogram human pluripotent stem cell-derived cells into brain endothelial cells with forebrain regional bias, improving BBB modeling.

The paper shows brain shuttle target expression varies between individuals but not by brain region, disease, age, or sex.

This study investigates how focused ultrasound opens the blood-brain barrier at low and high pressures, finding that low pressures cause transient tight junction reorganization while high pressures lead to irreversible damage.

This study shows Rab7a deletion reduces BBB dysfunction after ischemic stroke by preventing degradation of junctional proteins.

Molecular dynamic simulations reveal flavonoids self-assemble into ordered structures that interact with proteins, modulate enzyme activity, and protect cells from UV-induced injury.

This study shows that glutamatergic neuronal activity influences retinal angiogenesis and blood-retinal barrier maturation through Norrin/β-catenin signaling in mice.

The paper shows that cervical mucus from Organ Chips protects vaginal chips from inflammation and injury caused by bacterial vaginosis microbiomes, suggesting potential biomarkers and therapeutic targets.

This study shows that immunizing HLA-DRB1*15:01 mice with the alpha-synuclein epitope -syn32-46 causes intestinal inflammation, neuron loss, and constipation, mimicking prodromal Parkinson's disease features.

The paper uses cell type-specific proteomics in a MLIV mouse model to identify molecular mechanisms and dysregulated pathways in different brain cell types.

This study shows that Norrin/β-catenin signaling in mural cells increases Lama2 expression, which promotes neurovascular unit assembly and barrier maturation.