PhysiologyJCI InsightPeer-reviewed
The Unexpected Role of GCN2 Kinase Activation in Mediating Pulmonary Vascular Remodeling and Pulmonary Arterial Hypertension
Maggie M. Zhu, Jingbo Dai, Zhiyu Dai…·You‐Yang Zhao
This study shows GCN2 kinase activation in hypoxia mediates pulmonary vascular remodeling and PAH via Edn1, suggesting GCN2 as a therapeutic target for PAH.