Michael V. Airola

This study identifies a conserved NirD domain that mediates Nir1-Nir2 heterodimerization, enhancing PIP2 replenishment and expanding the dynamic range of the phosphatidylinositol cycle.

This study identifies nSMase2 as a metabolic tumor suppressor in breast cancer by restraining TAZ and inhibiting tumorigenesis.

This study presents five high-resolution structures of CpgD, revealing van der Waals interactions mediate its enantiomeric substrate preference for 2-phospho-D-glycerate.

This paper identifies DDHD2 as a neutral lipid lipase and transacylase that remodels triglyceride acyl chains by transferring acyl groups between lipids.

The paper presents high-resolution structures of Tt Pah2 in different catalytic states, revealing a conserved Asp-Arg motif critical for substrate recognition and catalysis.

The paper develops PILS-Nir1, a phosphatidic acid biosensor, and shows it detects PA dynamics in live cells with higher sensitivity than existing tools.

This study shows that CTDNEP1's regulatory subunit NEP1R1 controls its degradation to regulate ER membrane synthesis via lipin 1, but not lipid droplet biogenesis.

This study identifies CTDNEP1-NEP1R1 as a conserved membrane phosphatase complex that restricts ER expansion, with NEP1R1 activating CTDNEP1 through structural stabilization and substrate orientation.