Author
Broad InstituteORCID 0009-0001-3935-9083Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Nathaniel T. Kenton, Haim Michael Barr, Artem Cherepakha…·Alpha A. Lee
The paper identifies orally bioavailable inhibitors of the Zika virus NS2B-NS3 protease that show antiviral activity in vitro and reduce viral RNA load in a murine infection model.
Ed Griffen, D. Fearon, Briana Lynn McGovern…·Annette von Delft
This paper describes the optimization of a SARS-CoV-2 Mpro inhibitor to address genotoxic and metabolic liabilities, leading to improved in vivo efficacy and exposure.
Michelle R. Garnsey, Matthew C. Robinson, Luong T. Nguyen…·Alpha A. Lee
This study identifies potent SARS-CoV-2 PLpro inhibitors using machine learning, showing efficacy in a mouse model of COVID-19.
Alpha A. Lee, Isabelle Amick, Jasmin Cara Aschenbrenner…·Max Winokan
The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.
Roger L. Chang, Julian A. Stanley, Matthew C. Robinson…·Sabine Matallana‐Surget
The paper identifies molecular properties that determine oxidative stress resistance in bacteria by analyzing protein susceptibility to oxidation in Escherichia coli and Deinococcus radiodurans.