Cell BiologyGeroSciencePeer-reviewed
Age-associated failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging
Maria Grazia Perino, Miguel Calvo‐Rubio, Daniel R. Riordon…·Edward G. Lakatta
This study shows that aging impairs proteostatic mechanisms in mice with cardiac-specific over-expression of adenylyl cyclase VIII, leading to accelerated heart aging and cardiomyopathy.
6 citations