Jia-Hua Qu

This study shows that aging impairs proteostatic mechanisms in mice with cardiac-specific over-expression of adenylyl cyclase VIII, leading to accelerated heart aging and cardiomyopathy.

This study identifies transcriptomic changes in the sinoatrial node of mice overexpressing AC8, revealing altered pathways and transcription factors linked to cardiac aging and disease.

The paper develops a customized RNA-seq analysis pipeline using Nextflow and R, analyzing the effects of gene mutations and hormone treatments on transcriptomes in mice.

The paper integrates phosphoproteomics, proteomics, and transcriptomics to show that reprogramming of cardiac signaling pathways enhances resilience to chronic adenylyl cyclase stress.

The paper identifies 138 genes and variants associated with prenatal lethality across ethnic groups, suggesting preconception screening could identify couples at risk for miscarriage.

The paper compares age-related molecular changes in left ventricle and sinoatrial node cells from young and old C57 mice using transcriptomic analysis to identify age-associated gene expression patterns and regulatory mechanisms.