Author

Hawley Brown

Tufts UniversityORCID 0009-0001-9855-5877Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Joshua A. KritzeriD· 2 shared Alexandria N. LeveilleiD· 1 shared Alina ÜffingiD· 1 shared Andrew M. BaschnageliD· 1 shared Aniruddha Sunil KarveiD· 1 shared Bennett True· 1 shared Chenran WangiD· 1 shared Dan IonascuiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Joshua A. KritzerORCID

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2 papers

Recent·Most cited

BiochemistryACS Medicinal Chemistry LettersPeer-reviewedJan 6, 2025

Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP

Alexandria N. Leveille, Thomas Schwarzrock, Hawley Brown…·Joshua A. Kritzer

The paper investigates the binding affinity of GW5074 to LC3B and GABARAP using an AlphaScreen assay, finding micromolar inhibitory potencies and suggesting potential for targeted protein degradation.

8 citations

experimental assay

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Cancer BiologyCancersPeer-reviewedSep 15, 2024

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

Debanjan Bhattacharya, Riccardo Barrile, Donatien Kamdem Toukam…·Soma Sengupta

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

15 citations

mouseexperimental assay

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