ImmunologybioRxiv
Intracellular K+ limits T cell exhaustion and preserves antitumor function
Camille Collier, Kelly Wucherer, Matthew McWhorter…·Robert Eil
This study shows that lowering intracellular K+ in T cells by disrupting Na+/K+ ATPase reduces T cell exhaustion and improves antitumor function by mitigating ROS accumulation.
DOI 10.1158/2326-6066.cir-23-0319