ImmunologybioRxiv
Lung cancer-intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg-dependent CD8+ T cell exclusion
Elen Torres-Mejia, Sally Weng, Charlie A. Whittaker…·Stefani Spranger
This study identifies SOX2 expression in lung cancer cells as a mechanism causing resistance to checkpoint blockade by promoting Treg-dependent CD8+ T cell exclusion.
DOI 10.1158/2326-6066.cir-24-0184