Author
University of PittsburghORCID 0009-0002-4328-5344Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Andrew W. Simonson, Michael C. Chao, Luke E Hood…·JoAnne L. Flynn
The study shows that prior Mtb infection protects against reinfection with a genetically distinct strain in macaques, suggesting broad vaccine efficacy across Mtb lineages.
Pauline A Maiello, Collin R. Diedrich, Tara W. Rutledge…·Philana Ling Lin
The paper investigates TB relapse in a macaque model, finding that complete sterilization protects against relapse but PET CT cannot predict it, and that Mtb dissemination originates from both lung and lymph nodes.
Erin McCaffrey, Alea C. Delmastro, Isobel Fitzhugh…·Michael Angelo
This study identifies hypoxia as a key driver of immune dysfunction in TB granulomas, correlating with bacterial persistence.
Andrew W. Simonson, Joseph John Zeppa, Allison N. Bucşan…·JoAnne L. Flynn
The paper shows that CD4 T cells and innate CD8+ lymphocytes are essential for IV BCG-induced protection against tuberculosis in macaques.
Joshua D. Bromley, Sharie Keanne C. Ganchua, Sarah K. Nyquist…·JoAnne L. Flynn
The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.