Charles A. Scanga

The study shows that prior Mtb infection protects against reinfection with a genetically distinct strain in macaques, suggesting broad vaccine efficacy across Mtb lineages.

The paper profiles macrophage diversity in TB granulomas using single-cell RNA sequencing and immunofluorescence in nonhuman primates, identifying distinct subsets and their roles in Mtb infection.

This study identifies hypoxia as a key driver of immune dysfunction in TB granulomas, correlating with bacterial persistence.

The paper shows that CD4 T cells and innate CD8+ lymphocytes are essential for IV BCG-induced protection against tuberculosis in macaques.

The paper identifies a humoral correlate of protection against tuberculosis in humans and non-human primates, showing cross-species and vaccine regimen consistency.

The paper uses Markov Fields to integrate multi-modal immune data from vaccinated macaques, identifying critical immune interactions and predicting perturbation effects.

This study compares intravenous and intradermal BCG vaccination in SIV-infected macaques, finding IV BCG induces stronger airway and lung immune responses, including TRM cells and polyfunctional T cells.

The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.