Cell BiologyCell ReportsPeer-reviewed
A Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription
Jacob Kim, Shicong Xie, Lucas Fuentes Valenzuela…·Jan Marcel Skotheim
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Author
Lucas Fuentes Valenzuela
Stanford UniversityORCID 0009-0002-7403-3537Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 1/yrCo-Author Collaboration Network
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Curved chords = mutual co-authorship3 papers
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- Systems BiologyeLifePeer-reviewed
The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth
Lucas Fuentes Valenzuela, Paul François, Jan Marcel Skotheim
The paper confirms the Product neutrality function accurately predicts double mutant fitness in budding yeast and shows it emerges from mechanistic models of cell growth.
DOI 10.7554/elife.105265 - Molecular BiologyCellPeer-reviewed
RNA polymerase II dynamics and mRNA stability feedback determine mRNA scaling with cell size
Matthew P. Swaffer, Georgi K. Marinov, Huan Zheng…·Jan Marcel Skotheim
The paper identifies RNAPII as the limiting factor for transcription scaling with cell size in budding yeast and shows that mRNA stability feedback compensates for sub-linear transcription growth.
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