Matthew P. Swaffer

The paper shows that cell size affects mRNA concentrations, driving proteome changes through transcriptional regulation.

This study shows that yeast cells adapt to changes in mitochondrial DNA copy number through retrograde signaling and protein dosage compensation, allowing robust growth despite mtDNA fluctuations.

The paper shows that cell size affects SBF and Whi5 chromatin binding to regulate the Start transition in budding yeast by altering their copy-number ratio and chromatin affinity.

The paper shows that intracellular diffusion in fission yeast increases with cell size, linked to changes in proteome composition and DNA-to-cytoplasm ratio.

The paper shows genome concentration limits transcription and affects proteome composition in E. coli, with effects detectable in nutrient-rich conditions.

The paper shows that polyploidy in C. elegans intestine increases transcriptional output and supports biosynthesis by compensating for mRNA dilution through increased RNA Polymerase II loading.

The paper identifies RNAPII as the limiting factor for transcription scaling with cell size in budding yeast and shows that mRNA stability feedback compensates for sub-linear transcription growth.

This study maps 5-hydroxymethyluracil and chromatin accessibility in Breviolum minutum to explore their genomic distribution and functional roles.

This paper introduces SMAC-seq, a method for long-range chromatin accessibility mapping in eukaryotes, and demonstrates its application in yeast.