Yuanxin Chen

This study shows that the LRRK2-R1441G mutation causes age-related mitochondrial dysfunction and oxidative stress in dopamine neurons, suggesting calcium channels and uncoupling proteins as therapeutic targets.

This study shows that quinpirole improves microglial dysfunction in LRRK2-R1441G transgenic mice by reversing motility and responsiveness issues.

This study shows that PINK1 loss causes age-dependent mitochondrial trafficking deficits in dopaminergic neurons via p38 MAPK hyperactivation, leading to impaired mitochondrial motility and increased oxidative stress.

This study investigates the neuroenergetics of dopamine release in mouse striatal regions, finding that the dorsal striatum relies more on oxidative phosphorylation while the nucleus accumbens shell relies more on glycolysis.